Health across Generations

Health across Generations

The "Health across Generations” team conducts epidemiological research essentially based on the E3N and E4N cohorts.

Using the large database and biobank of the E3N and E4N cohorts, the team investigates how societal factors as well as individual factors (such as lifestyle and exposure to chemical pollutants) could be associated with the incidence and prognosis of the major non communicable chronic diseases. The team investigates those associations throughout the life course, within families and across several generations.

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Since 1990, the team has been actively following up the French E3N prospective cohort, composed of 98 995 women born between 1925 and 1950, and affiliated to the health insurance scheme of the national education system (MGEN). The team is now establishing the large E4N family cohort, including three generations of participants: the women of the E3N study and their spouses (already included), their children (inclusion 2018), and their grandchildren (inclusion 2020).

 In 2020, the mega-cohort E3N-E4N will bring together more than 20,000 families adding up 200,000 people from three successive generations.

Main lines of research:

  • To analyze the role of environmental and genetic factors, in the occurrence of and survival after cancer and other major chronic diseases (diabetes, cardiovascular diseases, neurological diseases...);
  • To more specifically investigate the associations with lifestyle, metabolic factors (e.g. diet and physical activity), the use of hormonal treatments, reproductive factors, and early life exposure;
  • To assess the relationship between chronic diseases and several biological markers (markers related to diet, hormonal status, genetic polymorphisms...);
  • To study the
    inheritance and the transmission of health determinants;
  • To study the link between genetic and epigenetic factors, and major chronic diseases (cancer, diabetes…).
Responsable(s)
Gianluca
SEVERI
Responsable d'équipe
Marie-Christine
BOUTRON-RUAULT
Co-responsable d'équipe
Localisation

Gustave Roussy

Espace Maurice Tubiana (-1)
114 rue Edouard Vaillant
94805 Villejuif cedex

 

Principaux Financeurs
Inserm
La Ligue nationale contre le cancer
ANR (Agence nationale de la Recherche)
Inca
Fondation ARC
Fondation de France
Union Européenne
Fédération française de cardiologie
Fondation Recherche Médicale
Anses
Université Paris-Sud
Collaborations/Partenaires
Inserm
Université Paris-Sud
MGEN
La Ligue nationale contre le Cancer
Gustave Roussy

Membres

Patrick
ARVEUX
Epidémiologiste
Ghizlane
BAJAWI
Assistant de recherche clinique
Caroline
BESSON
Epidémiologiste
Fabrice
BONNET
Epidémiologiste
Nathalie
BOUSCAREN
Epidémiologiste
Marie-Christine
BOUTRON-RUAULT
Co-responsable d'équipe
Franck
CARBONNEL
Medecin
Rafika
CHAIT
Assistant de recherche clinique
Emmanuelle
CORREIA
Diététicien
Courtney
DOW
Epidémiologiste
Guy
FAGHERAZZI
Epidémiologiste
Marie
FANGON
Assistant logistique et technique
Agnès
FOURNIER
Epidémiologiste
Juliette
GAMBARETTI
Biostatisticien
Amandine
GELOT
Biostatisticien
Pascale
GERBOUIN-REROLLE
Chef de projet
Roselyn
GOMES
Data Manager
Sofiane
HARIZI
Assistant logistique et technique
Lyan
HOANG
Informaticien
Anita
KOWAL
Data Manager
Marina
KVASKOFF
Chercheur
Camille
LAPLANCHE
Responsable communication
Yahya Abdelkerim
MAHAMAT SALEH
Epidémiologiste
Noële
MAITRE
Data Manager
Séverine
MAKHLOUFI
Assistant logistique et technique
Francesca Romana
MANCINI
Epidémiologiste
Hanane
OMICHESSAN
Epidémiologiste
Kalina
RAJAOBELINA
Epidémiologiste
Noëlle
ROBERT
Data Manager
Nadège
SENINA
Assistant logistique et technique
Gianluca
SEVERI
Responsable d'équipe

Dernières publications

Socio-economic factors associated with a healthy diet: results from the E3N study. Affret, Aurélie; Severi, Gianluca; Dow, Courtney; Rey, Grégoire; Delpierre, Cyrille; Boutron-Ruault, Marie-Christine; Clavel-Chapelon, Françoise; Fagherazzi, Guy. Public Health Nutrition. 2017; 1574-1583: p.1574-1583. doi:10.1017/S1368980017000222
Article
Coffee, tea and melanoma risk: findings from the European Prospective Investigation into Cancer and Nutrition. Caini, Saverio; Masala, Giovanna; Saieva, Calogero; Kvaskoff, Marina; Savoye, Isabelle; Sacerdote, Carlotta; Hemmingsson, Oskar; Hammer Bech, Bodil; Overvad, Kim; Tjønneland, Anne; Petersen, Kristina E. N.; Mancini, Francesca Romana; Boutron-Ruault, Marie-Christine; Cervenka, Iris; Kaaks, Rudolf; Kühn, Tilman; Boeing, Heiner; Floegel, Anna; Trichopoulou, Antonia; Valanou, Elisavet; Kritikou, Maria; Tagliabue, Giovanna; Panico, Salvatore; Tumino, Rosario; Bueno-de-Mesquita, H. B. As; Peeters, Petra H.; Veierød, Marit B.; Ghiasvand, Reza; Lukic, Marko; Quirós, José Ramón; Chirlaque, Maria-Dolores; Ardanaz, Eva; Salamanca Fernández, Elena; Larrañaga, Nerea; Zamora-Ros, Raul; Maria Nilsson, Lena; Ljuslinder, Ingrid; Jirström, Karin; Sonestedt, Emily; Key, Timothy J.; Wareham, Nick; Khaw, Kay-Tee; Gunter, Marc; Huybrechts, Inge; Murphy, Neil; Tsilidis, Konstantinos K.; Weiderpass, Elisabete; Palli, Domenico. International Journal of Cancer. 2017; 2246-2255: p.2246-2255. doi:10.1002/ijc.30659
Article
Time-Dependent Associations Between Body Composition, Physical Activity, and Current Asthma in Women: A Marginal Structural Modeling Analysis. Bédard, Annabelle; Serra, Ignasi; Dumas, Orianne; Basagaña, Xavier; Clavel-Chapelon, Françoise; Le Moual, Nicole; Sanchez, Margaux; Siroux, Valérie; Varraso, Raphaëlle; Garcia-Aymerich, Judith. American Journal of Epidemiology. 2017; 21-28: p.21-28. doi:10.1093/aje/kwx038
Article
Adipokines and inflammation markers and risk of differentiated thyroid carcinoma: The EPIC study. Dossus, Laure; Franceschi, Silvia; Biessy, Carine; Navionis, Anne-Sophie; Travis, Ruth C.; Weiderpass, Elisabete; Scalbert, Augustin; Romieu, Isabelle; Tjønneland, Anne; Olsen, Anja; Overvad, Kim; Boutron-Ruault, Marie-Christine; Bonnet, Fabrice; Fournier, Agnès; Fortner, Renee T.; Kaaks, Rudolf; Aleksandrova, Krasimira; Trichopoulou, Antonia; La Vecchia, Carlo; Peppa, Eleni; Tumino, Rosario; Panico, Salvatore; Palli, Domenico; Agnoli, Claudia; Vineis, Paolo; Bueno-de-Mesquita, Bas; Peeters, Petra H.; Skeie, Guri; Zamora-Ros, Raul; Chirlaque, María-Dolores; Ardanaz, Eva; Sánchez, Maria-Jose; Quirós, Jose Ramón; Dorronsoro, Miren; Sandström, Maria; Nilsson, Lena Maria; Schmidt, Julie A.; Khaw, Kay-Tee; Tsilidis, Konstantinos K.; Aune, Dagfinn; Riboli, Elio; Rinaldi, Sabina. International Journal of Cancer. 2017; : . doi:10.1002/ijc.31172
Article
Plasma microRNAs as biomarkers of pancreatic cancer risk in a prospective cohort study. Duell, Eric J.; Lujan-Barroso, Leila; Sala, Núria; Deitz McElyea, Samantha; Overvad, Kim; Tjonneland, Anne; Olsen, Anja; Weiderpass, Elisabete; Busund, Lill-Tove; Moi, Line; Muller, David; Vineis, Paolo; Aune, Dagfinn; Matullo, Giuseppe; Naccarati, Alessio; Panico, Salvatore; Tagliabue, Giovanna; Tumino, Rosario; Palli, Domenico; Kaaks, Rudolf; Katzke, Verena A.; Boeing, Heiner; Bueno-de-Mesquita, H. B. As; Peeters, Petra H.; Trichopoulou, Antonia; Lagiou, Pagona; Kotanidou, Anastasia; Travis, Ruth C.; Wareham, Nick; Khaw, Kay-Tee; Ramon Quiros, Jose; Rodríguez-Barranco, Miguel; Dorronsoro, Miren; Chirlaque, María-Dolores; Ardanaz, Eva; Severi, Gianluca; Boutron-Ruault, Marie-Christine; Rebours, Vinciane; Brennan, Paul; Gunter, Marc; Scelo, Ghislaine; Cote, Greg; Sherman, Stuart; Korc, Murray. International Journal of Cancer. 2017; 905-915: p.905-915. doi:10.1002/ijc.30790
Article

Thèses

Facteurs alimentaires, diabète de type 2 et rétinopathie diabétique. Dirigée par Guy Fagherazzi. Dow Courtney. []: Paris Sud; .
Thesis
Etude des associations entre facteurs nutritionnels et risque de cancers cutanés dans la cohorte E3N. Dirigée par Marina Kvaskoff. MAHAMAT SALEH Yahya Abdelkerim . []: Paris Sud; .
Thesis
Etude des facteurs prédictifs de la perte d'autonomie des femmes âgées à partir des données de la cohorte E3N. Dirigée par MC. Boutron-Ruault. Bouscaren Nathalie. []: Paris Sud; .
Thesis
Signatures épi(génomiques): inférences étiologiques et application aux études épidémiologiques. Dirigée par Gianluca Severi. Omichessan Hanane. []: Paris Sud; .
Thesis