Neuroepidemiology

Neuroepidemiology

Neuroepidemiology and motor ageing

Our group studies the determinants and consequences of motor decline during normal and pathological aging. Our objective is to identify characteristics that explain the heterogeneity of motor decline, through measures of walking speed and disability in longitudinal studies, with a particular interest for cardiovascular risk factors, health behaviors and sex hormones. Our work also focuses on the descriptive and etiologic epidemiology of two neurodegenerative diseases, Parkinson's disease and amyotrophic lateral sclerosis, through studies on the interactions between genetic susceptibility and environmental exposures.

Responsable(s)
Alexis
ELBAZ
Responsable d'équipe
Localisation

Hôpital Paul Brousse, Bat.15/16

16 av. Paul Vaillant-Couturier
94807 Villejuif


Principaux Financeurs
Inserm
ANR (Agence nationale de la Recherche)
ANSES
IReSP
JPND
Collaborations/Partenaires
Service de Neurologie, Hôpital de la Salpêtrière (J.C. Corvol, M. Vidailhet)
Consortium Geo-PD (http://geopd.can.ubc.ca/)
Consortium Interlace
E3N
Cohorte Constances
Etude des Trois Cités
Santé Publique France (Programme ‘Maladies neurodégénératives ‘, http://invs.santepubliquefrance.fr/fr../Dossiers-thematiques/Maladies-chroniques-et-traumatismes/Maladies-neurodegeneratives/Le-programme-de-surveillance-epidemiologique)

Membres

Fanny
ARTAUD
Biostatisticien
Marianne
CANONICO
Epidémiologiste
Cloé
DOMENIGHETTI
Epidémiologiste
Alexis
ELBAZ
Responsable d'équipe
Frédéric
MOISAN
Epidémiologiste
Laetitia
PERRIN
Statisticien
Pierre-Emmanuel
SUGIER
Biostatisticien
Tim
VLAAR
Epidémiologiste
Ke
ZHOU
Epidémiologiste

Dernières publications

Smoking and Parkinson disease: Evidence for gene-by-smoking interactions. Lee, P. C.; Ahmed, I.; Loriot, M. A.; Mulot, C.; Paul, K. C.; Bronstein, J. M.; Ritz, B.; Elbaz, A.. Neurology. 2018; e583-e592: p.e583-e592. doi:10.1212/wnl.0000000000004953
Article
The gait speed advantage of taller stature is lost with age. Elbaz, A.; Artaud, F.; Dugravot, A.; Tzourio, C.; Singh-Manoux, A.. Sci Rep. 2018; 1485: p.1485. doi:10.1038/s41598-018-19882-1
Article
NeuroChip, an updated version of the NeuroX genotyping platform to rapidly screen for variants associated with neurological diseases. Blauwendraat, C.; Faghri, F.; Pihlstrom, L.; Geiger, J. T.; Elbaz, A.; Lesage, S.; Corvol, J. C.; May, P.; Nicolas, A.; Abramzon, Y.; Murphy, N. A.; Gibbs, J. R.; Ryten, M.; Ferrari, R.; Bras, J.; Guerreiro, R.; Williams, J.; Sims, R.; Lubbe, S.; Hernandez, D. G.; Mok, K. Y.; Robak, L.; Campbell, R. H.; Rogaeva, E.; Traynor, B. J.; Chia, R.; Chung, S. J.; International Parkinson's Disease Genomics Consortium, Courage- P. D. Consortium; Hardy, J. A.; Brice, A.; Wood, N. W.; Houlden, H.; Shulman, J. M.; Morris, H. R.; Gasser, T.; Kruger, R.; Heutink, P.; Sharma, M.; Simon-Sanchez, J.; Nalls, M. A.; Singleton, A. B.; Scholz, S. W.. Neurobiol Aging. 2017; 247 e9-247 e13: p.247 e9-247 e13. doi:10.1016/j.neurobiolaging.2017.05.009
Article
Trends in Drug Prescription Rates for Dementia: An Observational Population-Based Study in France, 2006-2014. Francois, M.; Sicsic, J.; Elbaz, A.; Pelletier Fleury, N.. Drugs Aging. 2017; : . doi:10.1007/s40266-017-0481-7
Article
Farming and incidence of motor neuron disease: French nationwide study. Kab, S.; Moisan, F.; Elbaz, A.. Eur J Neurol. 2017; : . doi:10.1111/ene.13353
Article

Thèses

randomisation mendélienne et interactions gène-environnement dans la maladie de Parkinson Dirigé par Alexis Elbaz. Cloé Domenighetti. []: Paris Saclay; .
Thesis
Association entre l'exposition au plomb et aux solvants et les maladies neurodégénératives à partir des données du Système National des Données de Santé (SNDS). Dirigée par Alexis Elbaz & Frédéric Moisan. Vlaar Tim. []: Paris Sud; .
Thesis