Epidemiology of radiations

Epidemiology of radiations

This group’s work focuses on epidemiology of cancers and, more specifically, on the epidemiology of the effects of ionising radiation; the long-term iatrogenic effects of treatment of cancer and the outlook for patients treated for cancer or tumours.

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For several years, the group has been setting up and following cohorts of subjects exposed to very variable doses of ionising radiation. These include cohort ANGIO (a cohort of children treated with radiotherapy for haemangioma), cohort TOMENF (a cohort of children exposed to CT scans), VENUS (a cohort of patients treated for thyroid cancer), SURVSEIN (a cohort of women treated for breast cancer), TRAVNUCL (a cohort of employees of companies contracted to the French nuclear industry). The team is also involved in case-control studies: on the risk of thyroid cancer in Cuba, on thyroid cancer in French Polynesia and on risk factors for differentiated thyroid cancer in young subjects in Eastern France The group’s main cohort is that of the French Childhood Cancer Survivors Study (FCCSS), a national cohort of 20,000 subjects treated before the year 2000 for childhood cancer. The FCCSS is the continuation of the French contingent of the EURO2K historic cohort and is a component of the Hope-épi (Programme of Investment in the Future) project. The role of radiotherapy and chemotherapy on the outlook for children treated for solid tumours is explored by sending a self-administered questionnaire, the establishment of follow-up visits and estimation of the doses administered during radiotherapy both within and at a distance from the irradiation fields. BIOF is the biological tissue bank which consists of samples of saliva and blood taken from survivors in the FCCSS. The BIOF is to be used for a study of the genetic factors which might predispose to the development of iatrogenic disease in some patients treated for childhood cancer because of their increased susceptibility to anti-cancer therapies. In parallel, the group is developing software to be used to simulate radiotherapy and estimate the doses administered during this radiotherapy both within and at a distance from the irradiation fields. The study of the outcome for subjects treated for cancer, in particular in childhood, has become the principal research project of the team over the last five years. Prospects Our main short-term project is to complete work on the FCCSS national cohort of children cured of childhood cancer and its associated BIOF tissue bank. In addition, we are going to use data from the SNIIR-AM to continue to study the medical outcome in this cohort. We also intend to continue the analysis of the various cohorts we have established and to complete the work on the new specific software to estimate irradiation doses at a distance from external beam radiotherapy and validate it clinically.

Responsable(s)
Florent
DE VATHAIRE
Chercheur.se
Responsable d'équipe
Localisation

Hôpital Gustave Roussy, Bat. B2M

114 rue Edouard Vaillant
94805 Villejuif


Principaux Financeurs
Inserm
Programme Investissement d’Avenir
ARC
INCA
Collaborations/Partenaires
EDF

Membres

Rodrigue
ALLODJI
Chercheur.se
Biostatisticien.ne
Daniel
BEJARANO QUISOBONI
Doctorant.e
Epidémiologiste
Amel
BELHOUT
Ingénieur.e. ou technicien.ne
Assistant.e de recherche clinique
Amel
BOUMARAF
Ingénieur.e ou technicien.ne
Assistant.e de recherche clinique
Juliette
CHAPPAT
Ingénieur.e. ou technicien.ne
Biostatisticien.ne
Stefania
CHOUNTA
Doctorant.e
Epidémiologiste
Florent
DE VATHAIRE
Chercheur.se
Responsable d'équipe
Charlotte
DEMOOR
Chercheur.se
Epidémiologiste
Claire
DUCOS
Doctorant.e
Epidémiologiste
Brice
FRESNEAU
Chercheur.se
Epidémiologiste
Alfred Arnaud
GBETCHEDJI
Doctorant.e
Epidémiologiste
Nadia
HADDY
Chercheur.se
Epidémiologiste
Neige
JOURNY
Chercheur.se
Epidémiologiste
Isao
KOBAYASHI
Ingénieur.e. ou technicien.ne
Gestionnaire de base de données
Martine
LABBE
Ingénieur.e. ou technicien.ne
Assistant.e de recherche clinique
Imene
MANSOURI
Chercheur.se
Epidémiologiste
Aude
MITTON
Ingénieur.e. ou technicien.ne
Chef.fe de projet
Emmanuelle
QUESTE
Ingénieur.e. ou technicien.ne
Epidémiologiste
Carole
RUBINO
Chercheur.se
Epidémiologiste
Vincent
SOUCHARD
Ingénieur.e. ou technicien.ne
Data Manager
Cécile
TEINTURIER
Chercheur.se
Epidémiologiste
Thi Van trinh
TRAN
Doctorant.e
Epidémiologiste
Giao
VU-BEZIN
Ingénieur.e ou technicien.ne
Chef.fe de projet
Monia
ZIDANE
Doctorant.e
Epidémiologiste

Dernières publications

Risk Factors for Small Adult Height in Childhood Cancer Survivors. Demoor-Goldschmidt C, Allodji RS, Journy N, Rubino C, Zrafi WS, Debiche G, Llanas D, Veres C, Thomas-Teinturier C, Pacquement H, Vu-Bezin G, Fresneau B, Berchery D, Bolle S, Diallo I, Haddy N, de Vathaire F.. . 2020; : . doi:10.1200/JCO.19.02361
Article
Reiterative Radiofrequency Ablation in the Management of Pediatric Patients with Hepatoblastoma Metastases to the Lung, Liver, or Bone. Yevich, Steven; Calandri, Marco; Gravel, Guillaume; Fresneau, Brice; Brugières, Laurence; Valteau-Couanet, Dominique; Branchereau, Sophie; Chardot, Christophe; Aerts, Isabelle; de Baere, Thierry; Tselikas, Lambros; Deschamps, Frederic. Cardiovascular and Interventional Radiology. 2019; 41-47: p.41-47. doi:10.1007/s00270-018-2097-7
Article
Risk of subsequent primary leukaemias among 69,460 five-year survivors of childhood cancer diagnosed from 1940 to 2008 in Europe: A cohort study within PanCareSurFup. Allodji, Rodrigue S.; Hawkins, Mike M.; Bright, Chloe J.; Fidler-Benaoudia, Miranda M.; Winter, David L.; Alessi, Daniela; Fresneau, Brice; Journy, Neige; Morsellino, Vera; Bárdi, Edit; Bautz, Andrea; Byrne, Julianne; Feijen, Elizabeth Lieke Am; Teepen, Jop C.; Vu-Bezin, Giao; Rubino, Carole; Garwicz, Stanislaw; Grabow, Desiree; Gudmundsdottir, Thorgerdur; Guha, Joyeeta; Hau, Eva-Maria; Jankovic, Momcilo; Kaatsch, Peter; Kaiser, Melanie; Linge, Helena; Muraca, Monica; Llanas, Damien; Veres, Cristina; Øfstaas, Hilde; Diallo, Ibrahima; Mansouri, Imene; Ronckers, Cecile M.; Skinner, Roderick; Terenziani, Monica; Wesenberg, Finn; Wiebe, Thomas; Sacerdote, Carlotta; Jakab, Zsuzsanna; Haupt, Riccardo; Lähteenmäki, Päivi; Zaletel, Lorna Zadravec; Kuehni, Claudia E.; Winther, Jeanette F.; Michel, Gisela; Kremer, Leontien C. M.; Hjorth, Lars; Haddy, Nadia; de Vathaire, Florent; Reulen, Raoul C.. European Journal of Cancer (Oxford, England: 1990). 2019; 117: p.71-83. doi:10.1016/j.ejca.2019.05.013
Article
Behavior and Food Consumption Pattern of the French Polynesian Population in the 1960s –1970s. Drozdovitch, Vladimir; Bouville, André; Tetuanui, Tetuaura; Taquet, Marc; Gardon, Jacques; Xhaard, Constance; Ren, Yan; Doyon, Françoise; de Vathaire, Florent. Asian Pacific Journal of Cancer Prevention. 2019; 20: p.3667-3677. doi:10.31557/APJCP.2019.20.12.3667
Article
New insights in cisplatin and radiation-induced ototoxicity: A French Childhood Cancer Survivors Study (FCCSS).. Fresneau, Brice; Santos, Felicia; Allodji, Rodrigue; Fayech, Chiraz; Bolle, Stephanie; Vu-Bezin, Giao; Souchard, Vincent; Haddy, Nadia; Doz, Francois P.; Berchery, Delphine; Lemire, Pierre; Journy, Neige; Veres, Cristina; Brugieres, Laurence; Valteau-Couanet, Dominique; Diallo, Ibrahima; Dufour, Christelle; De Vathaire, Florent. Journal of Clinical Oncology. 2019; 37: p.10061-10061. doi:10.1200/JCO.2019.37.15_suppl.10061
Article

Thèses

Mortalité spécifique et événements iatrogènes peu étudiés survenant à très long terme après traitement d’un cancer de l’enfant. Tukenova Markhaba. []: Paris XI; .
Thesis
Identification des variants génétiques rares associés au risque de second cancer après traitement d'un cancer pédiatrique. Claire Ducos. []: ; .
Thesis
Analyses pronostiques en oncologie pédiatrique : Identification de facteurs de susceptibilité tumorale ou individuelle à l’efficacité et/ou à la toxicité des traitements anticancéreux utilisés chez l’enfant. Fresneau Brice. []: Paris Sud; .
Thesis
Prise en compte des distributions de doses aux tissus sains dans la prédiction des effets iatrogènes de la radiothérapie : Application à la radiothérapie des cancers pédiatriques.. CHOUNTA Stefania. []: ; .
Thesis