High-Dimensional Biostatistics

High-Dimensional Biostatistics

High-Dimensional Biostatistics for Drug Safety and Genomics (HiDiBiostat)

The team is interested in emerging statistical issues in public health and clinical research as access to and use of large-scale data increases. Drug safety assessment and predictive genomics are our two main areas of methodological development, both of which involve high-dimensional issues, notably with machine learning approaches.

Lire la suite

Our first axis is devoted to the evaluation of drugs in population, with methodological developments in pharmacoepidemiology and pharmacovigilance. We have a particular interest in vaccines and drugs taken during pregnancy. Our recent orientations also involve the exploitation of medico-administrative databases such as the National Health Data System (SNDS) in France. In pharmacoepidemiology, our objective is to develop statistical methods for the exploitation of SNDS data taking into account measured and unmeasured confounding. In addition, we are working on methods for estimating public health impact: the benefit-risk ratio of vaccines and attributable risk. In pharmacovigilance, we are developing methods for automatic signal detection aimed at exploiting the large databases of spontaneous reports and, more recently, of the SNDS. These methods are based on the statistical fields of high-dimensional variable selection and causality.

Our second axis carried by the Genostat group is devoted to predictive genomics and epidemiological genetics. The objectives are among others: (i) the development of integrative strategies that use various sources of "internal" (e.g. clinical samples) or "external" (e.g. databases) information, in particular internal multilayered information from genomics, transcriptomics and proteomics for prediction; (ii) the development of methods for association testing with rare variants, in particular for exome sequencing data.

Responsable(s)
Pascale
TUBERT-BITTER
Chercheur.se
Responsable d'équipe
Localisation

Hôpital Paul Brousse, Bat. 15/16

16 av, Paul Vaillant Couturier
94807 Villejuif


Membres

Ismail
AHMED
Chercheur.se
Biostatisticien.ne
Lucas
ANZELIN
Doctorant.e
Biostatisticien.ne
Jacques
BENICHOU
Chercheur.se
Biostatisticien.ne
Mélanie
BONNEAULT
Doctorant.e
Biostatisticien.ne
Philippe
BROET
Chercheur.se
Co-responsable d'équipe
Émeline
COURTOIS
Doctorant.e
Biostatisticien.ne
Romain
DEMAILLY
Chercheur.se associé.e
Julianne
DUHAZE
Doctorant.e
Statisticien.ne
Chi-Hong
DUONG
Doctorant.e
Biostatisticien.ne
Sylvie
ESCOLANO
Ingénieur.e. ou technicien.ne
Biostatisticien.ne
Andre
GILLIBERT
Doctorant.e
Biostatisticien.ne
Matthieu
HANF
Biostatisticien.ne
Liliane
MANITCHOKO
Doctorant.e
Biostatisticien.ne
Jacqueline
MILET
Doctorant.e
Biostatisticien.ne
Lucas
MORIN
Ingénieur.e ou technicien.ne
Biostatisticien.ne
Hervé
PERDRY
Chercheur.se
Biostatisticien.ne
Matthieu
PLUNTZ
Doctorant.e
Biostatisticien.ne
Catherine
QUANTIN
Chercheur.se
Epidémiologiste
Julien
SIMON
Doctorant.e
Epidémiologiste
Anne
THIÉBAUT
Chercheur.se
Biostatisticien.ne
Pascale
TUBERT-BITTER
Chercheur.se
Responsable d'équipe
Etienne
VOLATIER
Doctorant.e
Statisticien.ne

Dernières publications

Empirical assessment of case-based methods for identification of drugs associated with acute liver injury in the French National Healthcare System database (SNDS). Thurin, Nicolas H.; Lassalle, Régis; Schuemie, Martijn; Pénichon, Marine; Gagne, Joshua J.; Rassen, Jeremy A.; Benichou, Jacques; Weill, Alain; Blin, Patrick; Moore, Nicholas; Droz-Perroteau, Cécile. Pharmacoepidemiology and Drug Safety. 2020; : . doi:10.1002/pds.5161
Article
Weighted Kaplan-Meier estimators motivating to estimate HIV-1 RNA reduction censored by a limit of detection. Ahmed, Ismaïl; Flandre, Philippe. Statistics in Medicine. 2020; : . doi:10.1002/sim.8455
Article
Quantifying the Predictive Accuracy of a Polygenic Risk Score for Predicting Incident Cancer Cases : Application to the CARTaGENE Cohort. Duhazé, Julianne; Jantzen, Rodolphe; Payette, Yves; De Malliard, Thibault; Labbé, Catherine; Noisel, Nolwenn; Broët, Philippe. Frontiers in Genetics. 2020; 11: p.408. doi:10.3389/fgene.2020.00408
Article
Mixed logistic regression in genome-wide association studies. Milet, Jacqueline; Courtin, David; Garcia, André; Perdry, Hervé. BMC bioinformatics. 2020; 21: p.536. doi:10.1186/s12859-020-03862-2
Article
Seasonal influenza vaccine and Guillain-Barré syndrome: A self-controlled case series study. Grave, Clémence; Boucheron, Pauline; Rudant, Jérémie; Mikaeloff, Yann; Tubert-Bitter, Pascale; Escolano, Sylvie; Hocine, Mounia N.; Coste, Joël; Weill, Alain. Neurology. 2020; : . doi:10.1212/WNL.0000000000009180
Article