Integrative respiratory epidemiology

Integrative respiratory epidemiology

The team conducts research on chronic respiratory diseases, mainly asthma and Chronic Obstructive Pulmonary Disease (COPD), as well as rhinitis, with a focus on their multifactorial and heterogeneous aspects. The team develops research programs on early-life determinants of respiratory health in children and determinants of respiratory health in adults, identifies respiratory phenotypes and studies their evolution throughout the life course. Our research aim to improve primary and secondary prevention, to identify new risk factors, their impact and interactions, and to better understand by which mechanisms they affect respiratory health.

The team is a host center for postdoctoral fellows in the context of the European program (https://www.ersnet.org/professional-development/fellowships/respire-host-application-and-web-registry), and is a partner in the research network on air quality in Paris region (Réseau de Recherche sur la Qualité de l'Air en Ile-de-France, DIM "Domaine d'Intérêt Majeur Qi2, Qualité de l'Air, Impacts sur la Santé et Innovations Technologiques et Politiques", https://www.dim-qi2.fr/).

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More specifically, the research conducted by the team members focus on the study of :

  1. Associations of exposure to disinfectants and cleaning products in daycare and at home with incidence and persistence of respiratory symptoms in children (contact: N. Le Moual),
  2. Associations between daycare environment, nasal microbiota and respiratory health in children (contact: O. Dumas),
  3. Associations of occupational exposures with asthma and COPD in adults (contact: O. Dumas/N. Le Moual),
  4. Associations of nutritional factors (diet, physical activity, obesity) with asthma and COPD in adults (contact: R. Varraso),
  5. Associations of indoor exposure to molds with asthma, rhinitis and lung function (contact: B. Leynaert/R. Nadif),
  6. Associations of early menarche, menopause, hormone therapy and hormonal and metabolic status in men and women, with asthma, lung function decline and COPD throughout the life course (contact: B. Leynaert).

The team also conducts researches on:

  1. Mechanisms by which the environment affects respiratory health, using biological and genetic approaches (contact: R.Nadif/L.Orsi)
  2. Identification of asthma phenotypes/endotypes based on biological characteristics and the study their evolution (contact : L. Orsi),
  3. Characterization of rhinitis phenotypes/endotypes and study of their associations with exposure to air pollution (contact: R. Nadif).

The team uses causal inference approaches to take into account several risk factors and their joint effect, and unsupervised clustering approaches to identify phenotypes and endotypes.Our research is based on three cohorts lead or co-lead by the team: Asthma-E3N, CRESPI and EGEA; and in a number of French (Constances, Nutrinet-Santé, ELFE…), European (European Community Respiratory Health Survey [ECRHS]), and international cohorts (Nurses’ Health Studies [NHS, and NHSII], 35th Multicenter Airway Research Collaboration [MARC35], Tasmanian Longitudinal Health Study [TASH]…).

Localisation

Hôpital Paul Brousse, Bât Leriche

16 av, Paul Vaillant Couturier
94807 Villejuif


Principaux Financeurs
Inserm
ANSES
ADEME
ANR
PHRC
Fondation de France
Collaborations/Partenaires
Institut pour l'Avancée des Biosciences (IAB), équipe d’Épidémiologie Environnementale appliquée à la Reproduction et la Santé Respiratoire, Grenoble
Imperial College, Londres, Royaume Uni
Centre de Recherche en Épidémiologie et Statistiques (CRESS), équipe de Recherche en Epidémiologie Nutritionnelle (EREN), Bobigny
Inserm U1124 (T3S), Equipe d’épidémiologie génétique et génomique fonctionnelle des maladies multifactorielles, Paris
Inserm U1219, Equipe Epicene, Bordeaux
UMR CNRS 6249, chrono-environnement, et département de mycologie CHRU, Besançon
Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgique.umCenter for Environmental and Respiratory Health Research (CERH), University of Oulu, Finlande
ISGlobal, Barcelone, Espagne
Massachusetts General Hospital & Harvard Medical School, Boston, USA
Monash University, Melbourne, Australie

Membres

Philippe
AEGERTER
Chercheur.se
Epidémiologiste
Wassila
AIT-HADAD
Doctorant.e
Epidémiologiste
Ibrahim
BAKARI
Ingénieur.e ou technicien.ne
Biostatisticien.ne
Annabelle
BÉDARD
Chercheur.se
Epidémiologiste
Jean
BOUSQUET
Chercheur.se
Recherche clinique
Alexis
DESCATHA
Chercheur.se
Epidémiologiste
Orianne
DUMAS
Chercheur.se
Epidémiologiste
Anastasie
EWORO NCHAMA
Ingénieur.e ou technicien.ne
Chef.fe de projet
Beatrice
FARALDO MUNOZ
Ingénieur.e ou technicien.ne
Assistant.e de direction
Diane
GODEAU
Doctorant.e
Epidémiologiste
Clemence
GUILHIN
Ingénieur.e ou technicien.ne
Data Manager
Nicole
LE MOUAL
Ingénieur.e ou technicien.ne
Epidémiologiste
Pierre
LEMIRE
Doctorant.e
Epidémiologiste
Bénédicte
LEYNAERT
Chercheur.se
Epidémiologiste
Rachel
NADIF
Chercheur.se
Responsable d'équipe
Laurent
ORSI
Ingénieur.e ou technicien.ne
Epidémiologiste
Tai Olivier
PHAM
Chercheur.se associé.e
Epidémiologiste
Nicolas
ROCHE
Chercheur associé
Recherche clinique
Marine
SAVOURÉ
Doctorant.e
Epidémiologiste
Guillaume
SIT
Doctorant.e
Epidémiologiste
Tajidine
TSIAVA
Doctorant.e
Epidémiologiste
Raphaëlle
VARRASO
Chercheur.se
Co-responsable d'équipe

Dernières publications

The Role of Nutritional Factors in Asthma: Challenges and Opportunities for Epidemiological Research. Annabelle Bédard, Zhen Li, Wassila Ait-hadad, Carlos A. Camargo Jr., Bénédicte Leynaert, Christophe Pison, Orianne Dumas and Raphaëlle Varraso. . 2021; : . doi:org/10.3390/ijerph18063013
Article
Questionnaire as an alternative of skin prick tests to differentiate allergic from non-allergic rhinitis in epidemiological studies. Marine Savouré, Jean Bousquet, Emilie Burte, Jocelyne Just, Isabelle Pin, Valérie Siroux, Laurent Orsi, Bénédicte Jacquemin, Rachel Nadif. . 2021; :
Article
Profile of exposures and lung function in adults with asthma: An exposome approach in the EGEA study. Alicia Guillien, Johanna Lepeule, Emie Seyve, Nicole Le Moual, Isabelle Pin, Bruno Degano, Judith Garcia-Aymerich, Jean-Louis Pépin, Christophe Pison, Orianne Dumas, Raphaëlle Varraso, Valérie Siroux. Environmental Research. 2020; : . doi:10.1016/j.envres.2020.110422
Article
Endotypes identified by cluster analysis in asthmatics and non-asthmatics and their clinical characteristics at follow-up: the case-control EGEA study. Rachel Nadif ,Mickael Febrissy, Miora Valérie Andrianjafimasy ,Nicole Le Moual, Frederic Gormand, Jocelyne Just, Isabelle Pin,Valerie Siroux, Régis Matran, Orianne Dumas, Mohamed Nadif. BMJ Open Respiratory Research. 2020; 7: . doi:10.1136/ bmjresp-2020-000632
Article

Thèses

Phénotypes inflammatoires de l'asthme : caractérisation, évolution et association avec l'exposition aux moisissures de l'air intérieur dans la cohorte Constances . TSIAVIA Tajidine. []: Université Paris-Sud; 2020.
Thesis
Phenotypes de la rhinite : Identification et associaton avec l'exposition à long terme à la pollution atmosphérique dans deux études françaises. Savouré Marine. []: Université Paris-Sud; 2019.
Thesis
Etude épidémiologique des conditions de travail intervenant comme barrières dans la définition du handicap professionnel. Godeau Diane. []: Université de Versailles St Quentin en Yvelines; 2016.
Thesis