Integrative respiratory epidemiology

Integrative respiratory epidemiology

The team conducts research on chronic respiratory diseases, mainly asthma and Chronic Obstructive Pulmonary Disease (COPD), as well as rhinitis, with a focus on their multifactorial and heterogeneous aspects. The team develops research programs on early-life determinants of respiratory health in children and determinants of respiratory health in adults, identifies respiratory phenotypes and studies their evolution throughout the life course. Our research aim to improve primary and secondary prevention, to identify new risk factors, their impact and interactions, and to better understand by which mechanisms they affect respiratory health.

The team is a host center for postdoctoral fellows in the context of the European program (https://www.ersnet.org/professional-development/fellowships/respire-host-application-and-web-registry), and is a partner in the research network on air quality in Paris region (Réseau de Recherche sur la Qualité de l'Air en Ile-de-France, DIM "Domaine d'Intérêt Majeur Qi2, Qualité de l'Air, Impacts sur la Santé et Innovations Technologiques et Politiques", https://www.dim-qi2.fr/).

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More specifically, the research conducted by the team members focus on the study of :

  1. Associations of exposure to disinfectants and cleaning products in daycare and at home with incidence and persistence of respiratory symptoms in children (contact: N. Le Moual),
  2. Associations between daycare environment, nasal microbiota and respiratory health in children (contact: O. Dumas),
  3. Associations of occupational exposures with asthma and COPD in adults (contact: O. Dumas/N. Le Moual),
  4. Associations of nutritional factors (diet, physical activity, obesity) with asthma and COPD in adults (contact: R. Varraso),
  5. Associations of indoor exposure to molds with asthma, rhinitis and lung function (contact: B. Leynaert/R. Nadif),
  6. Associations of early menarche, menopause, hormone therapy and hormonal and metabolic status in men and women, with asthma, lung function decline and COPD throughout the life course (contact: B. Leynaert).

The team also conducts researches on:

  1. Mechanisms by which the environment affects respiratory health, using biological and genetic approaches (contact: R.Nadif/L.Orsi)
  2. Identification of asthma phenotypes/endotypes based on biological characteristics and the study their evolution (contact : L. Orsi),
  3. Characterization of rhinitis phenotypes/endotypes and study of their associations with exposure to air pollution (contact: R. Nadif).

The team uses causal inference approaches to take into account several risk factors and their joint effect, and unsupervised clustering approaches to identify phenotypes and endotypes.Our research is based on three cohorts lead or co-lead by the team: Asthma-E3N, CRESPI and EGEA; and in a number of French (Constances, Nutrinet-Santé, ELFE…), European (European Community Respiratory Health Survey [ECRHS]), and international cohorts (Nurses’ Health Studies [NHS, and NHSII], 35th Multicenter Airway Research Collaboration [MARC35], Tasmanian Longitudinal Health Study [TASH]…).

Localisation

Hôpital Paul Brousse, Bât Leriche

16 av, Paul Vaillant Couturier
94807 Villejuif


Principaux Financeurs
Inserm
ANSES
ADEME
ANR
PHRC
Fondation de France
Collaborations/Partenaires
Institut pour l'Avancée des Biosciences (IAB), équipe d’Épidémiologie Environnementale appliquée à la Reproduction et la Santé Respiratoire, Grenoble
Imperial College, Londres, Royaume Uni
Centre de Recherche en Épidémiologie et Statistiques (CRESS), équipe de Recherche en Epidémiologie Nutritionnelle (EREN), Bobigny
Inserm U1124 (T3S), Equipe d’épidémiologie génétique et génomique fonctionnelle des maladies multifactorielles, Paris
Inserm U1219, Equipe Epicene, Bordeaux
UMR CNRS 6249, chrono-environnement, et département de mycologie CHRU, Besançon
Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgique.umCenter for Environmental and Respiratory Health Research (CERH), University of Oulu, Finlande
ISGlobal, Barcelone, Espagne
Massachusetts General Hospital & Harvard Medical School, Boston, USA
Monash University, Melbourne, Australie

Membres

Philippe
AEGERTER
Chercheur.se
Epidémiologiste
Wassila
AIT-HADAD
Chercheur.se
Epidémiologiste
Oualid
ALIOUI
Ingénieur.e ou technicien.ne
Assistant.e de recherche clinique
Flore
AMAT
Chercheur.se
Epidémiologiste
Ibrahim
BAKARI
Doctorant.e
Epidémiologiste
Annabelle
BÉDARD
Chercheur.se
Epidémiologiste
Jean
BOUSQUET
Chercheur.se associé.e
Recherche clinique
Franziska
BRIGHT
Ingénieur.e ou technicien.ne
Statisticien.ne
Rosalie
DELVERT
Doctorant.e
Epidémiologiste
Alexis
DESCATHA
Chercheur.se associé.e
Epidémiologiste
Marie-Helene
DIZIER
Chercheur.se
Epidémiologiste
Orianne
DUMAS
Chercheur.se
Epidémiologiste
Beatrice
FARALDO MUNOZ
Ingénieur.e ou technicien.ne
Assistant.e de direction
Diane
GODEAU
Chercheur.se associé.e
Epidémiologiste
Helene
GOUZE
Doctorant.e
Hervé
LABORDE-CASTÉROT
Chercheur.se associé.e
Epidémiologiste
Nicole
LE MOUAL
Ingénieur.e ou technicien.ne
Epidémiologiste
Bénédicte
LEYNAERT
Chercheur.se
Epidémiologiste
Rachel
NADIF
Chercheur.se
Responsable d'équipe
Claire
NEVEU
Ingénieur.e ou technicien.ne
Enquęteur.trice
Laurent
ORSI
Ingénieur.e ou technicien.ne
Epidémiologiste
Emilie
PACHECO DA SILVA
Doctorant.e
Epidémiologiste
Tai Olivier
PHAM
Chercheur.se
Epidémiologiste
Nicolas
ROCHE
Chercheur.se associé.e
Recherche clinique
Ioannis
SAKELLARIS
Chercheur.se
Epidémiologiste
Tajidine
TSIAVA
Chercheur.se
Epidémiologiste
Raphaëlle
VARRASO
Chercheur.se
Co-responsable d'équipe

Dernières publications

Healthful and Unhealthful Plant-Based Diets and Chronic Obstructive Pulmonary Disease in U.S. Adults: Prospective Study. Varraso, Raphaëlle; Dumas, Orianne; Tabung, Fred K.; Boggs, Krislyn M.; Fung, Teresa T.; Hu, Frank; Giovannucci, Edward; Speizer, Frank E.; Willett, Walter C.; Camargo, Carlos A.. Nutrients. 2023; 15: p.765. doi:10.3390/nu15030765
Article
Plasma thymic stromal lymphopoietin (TSLP) in adults with non-severe asthma: the EGEA study. Ibrahim, Bakari; Achour, Djamal; Zerimech, Farid; Nadai, Patricia de; Siroux, Valerie; Tsicopoulos, Anne; Matran, Régis; Granger, Vanessa; Nadif, Rachel. Thorax. 2023; 78: p.207-210. doi:10.1136/thorax-2022-219192
Article
The exposome in respiratory diseases: multiple preventable risk factors from early life to adulthood. Savouré, Marine; Eminson, Katie; Sese, Lucile; Dumas, Orianne; Cai, Yutong Samuel. Breathe. 2023; 19: . doi:10.1183/20734735.0034-2023
Article
Update on irritant-induced occupational asthma. Ronsmans, Steven; Le Moual, Nicole; Dumas, Orianne. Current Opinion in Allergy and Clinical Immunology. 2023; 23: p.63. doi:10.1097/ACI.0000000000000884
Article
Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study. Pham, Tài; Heunks, Leo; Bellani, Giacomo; Madotto, Fabiana; Aragao, Irene; Beduneau, Gaëtan; Goligher, Ewan C.; Grasselli, Giacomo; Laake, Jon Henrik; Mancebo, Jordi; Peñuelas, Oscar; Piquilloud, Lise; Pesenti, Antonio; Wunsch, Hannah; Haren, Frank van; Brochard, Laurent; Laffey, John G.; Abrough, Fekri; Acharya, Subhash P.; Amin, Pravin; Arabi, Yaseen; Aragao, Irene; Bauer, Philippe; Beduneau, Gaëtan; Beitler, Jeremy; Berkius, Johan; Bugedo, Guillermo; Camporota, Luigi; Cerny, Vladimir; Cho, Young-Jae; Clarkson, Kevin; Estenssoro, Elisa; Goligher, Ewan; Grasselli, Giacomo; Gritsan, Alexey; Hashemian, Seyed Mohammadreza; Hermans, Greet; Heunks, Leo M.; Jovanovic, Bojan; Kurahashi, Kiyoyasu; Laake, Jon Henrik; Matamis, Dimitrios; Moerer, Onnen; Molnar, Zsolt; Ozyilmaz, Ezgi; Panka, Bernardo; Papali, Alfred; Peñuelas, Óscar; Perbet, Sébastien; Piquilloud, Lise; Qiu, Haibo; Razek, Assem Abdel; Rittayamai, Nuttapol; Roldan, Rollin; Neto, Ary Serpa; Szuldrzynski, Konstanty; Talmor, D. The Lancet Respiratory Medicine. 2023; 11: p.465-476. doi:10.1016/S2213-2600(22)00449-0
Article

Thèses en cours

RHUMATISMES INFLAMMATOIRES CHRONIQUES ET COMORBIDITÉS : ANALYSE DE LA COHORTE EN POPULATION GÉNÉRALE CONSTANCES. Gouze, Helene; Aegerter, Philippe; Breban, Maxime. []: université Paris-Saclay; 2022.
Thesis
Utilisation à domicile de produits de nettoyage et santé respiratoire – évolution de cet usage, en lien avec la pandémie de COVID-19 – dans deux grandes cohortes françaises. Pacheco da silva, Emilie; Le moual, Nicole. []: université Paris-Saclay; 2021.
Thesis
Etude de l'association entre le régime alimentaire maternel pendant la grossesse et le développement de maladies respiratoires et allergiques chez l'enfant.. Delvert, Rosalie; Varraso, Raphaelle; Bedard, Annabelle; De lauzon-guillain, Blandine. []: université Paris-Saclay; 2021.
Thesis

Thèses soutenues

Phenotypes of rhinitis : identification and association with long-term exposure to air pollution in two French studies. Savouré, Marine; Nadif, Rachel; Jacquemin, Bénédicte. []: université Paris-Saclay; 2023.
Thesis
Phénotypes inflammatoires de l'asthme : caractérisation, évolution et association avec l'exposition aux moisissures de l'air intérieur dans la cohorte Constances . TSIAVIA Tajidine. []: Université Paris-Sud; 2020.
Thesis
Etude épidémiologique des conditions de travail intervenant comme barrières dans la définition du handicap professionnel. Godeau Diane. []: Université de Versailles St Quentin en Yvelines; 2016.
Thesis