Our team investigates how the individual factors that constitute the exposome (health behaviors, lifestyle, occupation, environmental exposures to chemical or physical pollutants, biological characteristics, etc.), and the genetic background interact to influence the incidence and outcome of common chronic conditions such as cancer, cardio-metabolic conditions, and neuro-degenerative and ageing-related diseases. Thus, the team aims at assessing in detail the joint exposure to multiple risk factors, and studying their relation to disease incidence over the lifecourse, as well as the influence on disease prognosis. One of our specificities is that we will be able to study the effect of the exposome across generations, and the transmission of traits within families across several generations.
This research program mainly relies on the E3N-E4N familial prospective cohort, large disease-specific case-control studies, and medico-administrative databases such as those from the health insurance schemes, MGEN and the French social security.
Our team includes over 70 people and is structured along three main axes: the research axis, the statistics and methodology axis, and the technical services.