Exposome and Heredity

Exposome and Heredity

Exposome and Heredity

Our team investigates how the individual factors that constitute the exposome (health behaviors, lifestyle, occupation, environmental exposures to chemical or physical pollutants, biological characteristics, etc.), and the genetic background interact to influence the incidence and outcome of common chronic conditions such as cancer, cardio-metabolic conditions, and neuro-degenerative and ageing-related diseases.  Thus, the team aims at assessing in detail the joint exposure to multiple risk factors, and studying their relation to disease incidence over the lifecourse, as well as the influence on disease prognosis. One of our specificities is that we will be able to study the effect of the exposome across generations, and the transmission of traits within families across several generations.

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This research program mainly relies on the E3N-E4N familial prospective cohort, large disease-specific case-control studies, and medico-administrative databases such as those from the health insurance schemes, MGEN and the French social security.

Our team includes over 70 people and is structured along three main axes: the research axis, the statistics and methodology axis, and the technical services.

https://www.e3n.fr/

https://www.e4n.fr/

 

Responsable(s)
Gianluca
SEVERI
Chercheur.se
Responsable d'équipe

Principaux Financeurs
Inserm
La Ligue nationale contre le cancer
ANR (Agence nationale de la Recherche)
Inca
Fondation ARC
Fondation de France
Union Européenne
Fédération française de cardiologie
Fondation Recherche Médicale
Anses
Université Paris-Sud
Collaborations/Partenaires
Inserm
Gustave Roussy
MGEN
La Ligue nationale contre le Cancer
Université Paris-Sud

Membres

Alaa
ABDEL HADI
Ingénieur.e. ou technicien.ne
Data Manager
Marie
AL RAHMOUN
Doctorant.e
Epidémiologiste
Isabelle
ALLOU
Ingénieur.e. ou technicien.ne
Data Manager
Mariam
ALYANAKIAN
Ingénieur.e. ou technicien.ne
Data Manager
Fanny
ARTAUD
Ingénieur.e ou technicien.ne
Biostatisticien.ne
Alpha
BARRY
Ingénieur.e. ou technicien.ne
Data Manager
Caroline
BESSON
Chercheur.se
Epidémiologiste
Wendy
BIJOUX
Doctorant.e
Epidémiologiste
Régine
BILLMANN
Ingénieur.e. ou technicien.ne
Chef.fe de projet
Marianne
CANONICO
Chercheur.se
Epidémiologiste
Sylvie
CENEE
Ingénieur.e. ou technicien.ne
Statisticien.ne
Emmanuelle
CORREIA
Ingénieur.e. ou technicien.ne
Data Manager
Cloe
DOMENIGHETTI
Doctorant.e
Epidémiologiste
Douae
EL FATOUHI
Doctorant.e
Alexis
ELBAZ
Chercheur.se
Co-responsable d'équipe
Mélody
ENGUIX
Ingénieur.e. ou technicien.ne
Community manager
Elodie
FAURE
Ingénieur.e. ou technicien.ne
Chef.fe de projet
Thibault
FIOLET
Doctorant.e
Epidémiologiste
Annick
FONTBONNE
Chercheur.se
Epidémiologiste
Agnès
FOURNIER
Ingénieur.e ou technicien.ne
Epidémiologiste
Pauline
FRENOY
Ingénieur.e. ou technicien.ne
Statisticien.ne
Amandine
GELOT
Ingénieur.e. ou technicien.ne
Biostatisticien.ne
Roselyn
GOMES
Ingénieur.e. ou technicien.ne
Data Manager
Pascal
GUENEL
Chercheur.se
Co-responsable d'équipe
Julie
GUIBON
Doctorant.e
Epidémiologiste
Mariem
HAJJI
Doctorant.e
Epidémiologiste
Sofiane
HARIZI
Ingénieur.e. ou technicien.ne
Informaticien.ne
Lyan
HOANG
Ingénieur.e. ou technicien.ne
Informaticien.ne
Rahime
KABORE
Ingénieur.e. ou technicien.ne
Data Manager
Mojgan
KARIMI
Ingénieur.e. ou technicien.ne
Data Manager
Anita
KOWAL
Ingénieur.e ou technicien.ne
Marina
KVASKOFF
Chercheur.se
Epidémiologiste
Maryline
LAINE
Doctorant.e
Epidémiologiste
Nasser
LAOUALI MAHAMADOU
Chercheur.se
Epidémiologiste
Camille
LAPLANCHE
Ingénieur.e ou technicien.ne
Céline
LAVALETTE
Doctorant.e
Epidémiologiste
Lucie
LÉCUYER
Chercheur.se
Epidémiologiste
Clémentine
LEMARCHAND
Chercheur.se
Epidémiologiste
Lisa
LEUNG
Doctorant.e
Epidémiologiste
Elise
LUCOTTE
Chercheur.se
Biostatisticien.ne
Conor James
MACDONALD
Chercheur.se
Epidémiologiste
Yahya Abdelkerim
MAHAMAT SALEH
Doctorant.e
Epidémiologiste
Noële
MAITRE
Ingénieur.e. ou technicien.ne
Data Manager
Francesca Romana
MANCINI
Chercheur.se
Epidémiologiste
Mireille
MATRAT
Chercheur.se
Médecin
Florence
MENEGAUX
Chercheur.se
Epidémiologiste
Fatima
MOHAMED
Ingénieur.e. ou technicien.ne
Statisticien.ne
Frédéric
MOISAN
Chercheur associé
Epidémiologiste
Thi Thu ha
NGUYEN
Chercheur.se
Epidémiologiste
Mélanie
PAQUET
Doctorant.e
Epidémiologiste
Laetitia
PERRIN
Ingénieur.e. ou technicien.ne
Statisticien.ne
Giancarlo
PESCE
Chercheur.se
Statisticien.ne
Denis-Louis
PIERRE
Ingénieur.e. ou technicien.ne
Data Manager
Berta
PORTUGAL
Doctorant.e
Epidémiologiste
Lorédana
RADOI
Chercheur.se
Epidémiologiste
Joseph
ROTHWELL
Chercheur.se
Jennifer
RUSMAULLY
Doctorant.e
Epidémiologiste
Felicia
SANTOS
Ingénieur.e ou technicien.ne
Statisticien.ne
Gianluca
SEVERI
Chercheur.se
Responsable d'équipe
Pierre-Emmanuel
SUGIER
Chercheur.se
Epidémiologiste
Thérèse
TRUONG
Chercheur.se
Epidémiologiste

Dernières publications

Vitamin B6 catabolism and lung cancer risk: results from the Lung Cancer Cohort Consortium (LC3). Zuo, H.; Ueland, P. M.; Midttun, Ø; Tell, G. S.; Fanidi, A.; Zheng, W.; Shu, X.; Xiang, Y.; Wu, J.; Prentice, R.; Pettinger, M.; Thomson, C. A.; Giles, G. G.; Hodge, A.; Cai, Q.; Blot, W. J.; Johansson, M.; Hultdin, J.; Grankvist, K.; Stevens, V. L.; McCullough, M. L.; Weinstein, S. J.; Albanes, D.; Ziegler, R. G.; Freedman, N. D.; Caporaso, N. E.; Langhammer, A.; Hveem, K.; Næss, M.; Buring, J. E.; Lee, I.; Gaziano, J. M.; Severi, G.; Zhang, X.; Stampfer, M. J.; Han, J.; Zeleniuch-Jacquotte, A.; Marchand, L. L.; Yuan, J.; Wang, R.; Koh, W.; Gao, Y.; Ericson, U.; Visvanathan, K.; Jones, M. R.; Relton, C.; Brennan, P.; Johansson, M.; Ulvik, A.. Annals of Oncology: Official Journal of the European Society for Medical Oncology. 2019; : . doi:10.1093/annonc/mdz002
Article
Comparison of prognostic models to predict the occurrence of colorectal cancer in asymptomatic individuals: a systematic literature review and external validation in the EPIC and UK Biobank prospective cohort studies. Smith, Todd; Muller, David C.; Moons, Karel G. M.; Cross, Amanda J.; Johansson, Mattias; Ferrari, Pietro; Fagherazzi, Guy; Peeters, Petra H. M.; Severi, Gianluca; Hüsing, Anika; Kaaks, Rudolf; Tjonneland, Anne; Olsen, Anja; Overvad, Kim; Bonet, Catalina; Rodriguez-Barranco, Miguel; Huerta, Jose Maria; Barricarte Gurrea, Aurelio; Bradbury, Kathryn E.; Trichopoulou, Antonia; Bamia, Christina; Orfanos, Philippos; Palli, Domenico; Pala, Valeria; Vineis, Paolo; Bueno-de-Mesquita, Bas; Ohlsson, Bodil; Harlid, Sophia; Van Guelpen, Bethany; Skeie, Guri; Weiderpass, Elisabete; Jenab, Mazda; Murphy, Neil; Riboli, Elio; Gunter, Marc J.; Aleksandrova, Krasimira Jekova; Tzoulaki, Ioanna. Gut. 2019; 68: p.672-683. doi:10.1136/gutjnl-2017-315730
Article
Population attributable fractions of the main type 2 diabetes mellitus risk factors in women: Findings from the French E3N cohort. Rajaobelina, Kalina; Dow, Courtney; Romana Mancini, Francesca; Dartois, Laureen; Boutron-Ruault, Marie-Christine; Balkau, Beverley; Bonnet, Fabrice; Fagherazzi, Guy. Journal of Diabetes. 2019; 11: p.242-253. doi:10.1111/1753-0407.12839
Article
Association of Plasma Vitamin D Metabolites With Incident Type 2 Diabetes: EPIC-InterAct Case-Cohort Study. Zheng, Ju-Sheng; Imamura, Fumiaki; Sharp, Stephen J.; van der Schouw, Yvonne T.; Sluijs, Ivonne; Gundersen, Thomas E.; Ardanaz, Eva; Boeing, Heiner; Bonet, Catalina; Gómez, Jesus Humberto; Dow, Courtney; Fagherazzi, Guy; Franks, Paul W.; Jenab, Mazda; Kühn, Tilman; Kaaks, Rudolf; Key, Timothy J.; Khaw, Kay-Tee; Lasheras, Cristina; Mokoroa, Olatz; Mancini, Francesca Romana; Nilsson, Peter M.; Overvad, Kim; Panico, Salvatore; Palli, Domenico; Rolandsson, Olov; Sieri, Sabina; Salamanca-Fernández, Elena; Sacerdote, Carlotta; Spijkerman, Annemieke M. W.; Stepien, Magdalena; Tjonneland, Anne; Tumino, Rosario; Butterworth, Adam S.; Riboli, Elio; Danesh, John; Langenberg, Claudia; Forouhi, Nita G.; Wareham, Nicholas J.. The Journal of Clinical Endocrinology and Metabolism. 2019; 104: p.1293-1303. doi:10.1210/jc.2018-01522
Article
Relation between hysterectomy, oophorectomy and the risk of incident differentiated thyroid cancer: The E3N cohort. Guenego, Agathe; Mesrine, Sylvie; Dartois, Laureen; Leenhardt, Laurence; Clavel-Chapelon, Françoise; Kvaskoff, Marina; Boutron-Ruault, Marie-Christine; Bonnet, Fabrice. Clinical Endocrinology. 2019; 90: p.360-368. doi:10.1111/cen.13899
Article